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pregnancy and cancer risk

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pregnancy and cancer risk

Your risk becomes lower the more children you have and the earlier you begin your family. Epub 2018 Apr 10.  |  She's an assistant professor in the School of Global Public Health at the University of North Carolina. The first by the Collaborative Group on Hormonal Factors in Breast Cancer published in 2004 , included 52 studies. Pregnancy’s effects depend on your age when you first give birth. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Although pregnancy protection is associated with maternal age during her first pregnancy, the overall risk of developing breast cancer increases immediately follow parturition, and is independent of race, age, or the number of pregnancies 11, 12, 17. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. For some survivors, getting pregnant may require stopping certain medications. Please enable it to take advantage of the complete set of features! In general, your risk for developing cancer during pregnancy is low. Possible mechanisms of action include changes to the hormonal profile of parous women, a more differentiated and so less susceptible mammary gland or changes within specific epithelial cell subpopulations. Certain types of cancer were associated with the highest risk of preterm birth. As cancer is a major contributor to morbidity and mortality worldwide, identifying groups at risk is essential for early detection of disease. After that, it drops below the risk … Although a first pregnancy may increase the short-term risk of breast cancer, it lowers the long-term risk. That's the conclusion of a new study of more than 15,000 births to teen and young adult women, aged 15 to 39, living in North Carolina. Relationship Between Pregnancy and Breast Cancer Risk. 1998 Jan;3(1):7-22. doi: 10.1023/a:1018766000275. 2005;7(3):131-42. doi: 10.1186/bcr1029. A risk factor is anything that can increase your chance of developing a disease or condition. The risks were highest among women diagnosed with cancer during pregnancy. NIH Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions. For example, women who took the synthetic estrogen diethylstilbestrol (DES) during pregnancy are at an increased risk of developing breast cancer, as are women who suffered from severe pregnancy nausea or who gave birth to heavy newborns. Those who were cancer survivors had a higher risk for preterm birth, cesarean delivery and low birth weight infants, the researchers said. For example, a Pap test done as a part of standard pregnancy care can find cervical cancer, or an ultrasound done during pregnancy can find ovarian cancer. For example, in women who have a first full-term pregnancy before age 20, the risk of developing breast cancer is about half that of women whose first full-term pregnancy occurs after the age of 30 (4). Each condition has different risk factors. It is well established that childless women and women having children later in life are at an increased risk of developing breast cancer. We also explore the mechanisms by which parity protects, with a particular emphasis on the role of stem cells and the interactions between stem cells and estrogen. Several studies have made strong efforts to understand how age and parity modulate the risk of breast cancer. Nevertheless, it remains unclear how parity decreases breast cancer risk. "We found that women were more likely to deliver preterm if they've been treated for cancer overall, with greater risks for women who had chemotherapy," Nichols said in a university news release. doi: 10.1186/bcr2589. When breast cells are made in adolescence, they are immature and very active until your first full-term pregnancy. Rates of preterm birth -- delivery before 37 weeks -- were 13 percent among cancer survivors and 9 percent among those with no history of cancer. A full‐term pregnancy is associated with reduced endometrial cancer risk; however, whether the effect of additional pregnancies is independent of age at last pregnancy is unknown. Epub 2020 May 13. Within 5 months postpartum, you are at high risk for breast cancer, but the risk gradually decreases and … Pregnancy doesn’t cause cancer, and in most cases, being pregnant won’t make cancer grow faster in your body. © 2005 - 2019 WebMD LLC. All rights reserved. But there is no scientific proof that cancer risk increases if a woman gets pregnant within 2 years of completing treatment. Evaluation of the association between mammographic density and the risk of breast cancer using Quantra software and the BI-RADS classification. The risks were highest among women diagnosed with cancer during pregnancy. WebMD does not provide medical advice, diagnosis or treatment. 2020 May 27;11(1):2649. doi: 10.1038/s41467-020-16479-z. Subjects : Cases were 2279 multiparous women residents of eight areas aged 25-49 who were diagnosed as having breast cancer during 1980-2. Every pregnancy potentially reduces a woman's risk of developing endometrial cancer, new research has found. Pregnancy and Cancer Risk. Setting : Eight areas in the United States. HHS 2018 Jun;237(3):323-336. doi: 10.1530/JOE-17-0582. New Queensland research has found that each full-term pregnancy reduces the risk of endometrial cancer by 15 per cent for each baby. Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast. 2020 Nov 13;99(46):e23112. Northern Westchester Hospital, Mt. Some studies even suggest that risk of breast cancer recurrence is lower after a subsequent pregnancy. Breast cancer risk is slightly increased for about 10 years after a first birth. Clipboard, Search History, and several other advanced features are temporarily unavailable. In the research, Nichols team compared complication rates between 2,600 births to teen and young adults cancer survivors and nearly 13,000 births to women in the same age group with no history of cancer. The cancer survivors had a higher risk for preterm birth, cesarean delivery and low birth weight infants, the researchers found. 1-3 . She's co-chief of ambulatory care in Women's Health Programs at Northwell Health in New Hyde Park, N.Y. In breast cancer, there are a number of chemotherapy agents that have been shown to be safe and may be used as treatment in the second trimester of pregnancy,” Grumley explains. It’s known that a woman’s risk of developing breast cancer is related to her exposure to estrogen and progesterone — two hormones produced by the ovaries. USA.gov. Pregnancy-related factors and the risk of breast carcinoma in situ and invasive breast cancer among postmenopausal women in the California Teachers Study cohort. Kisco, NY; Â, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, Liver Cancer: Symptoms, Tests, and Treatments, Understanding Cancer Diagnosis and Treatment. This protective effect is specific for estrogen receptor positive breast cancer. Keywords Breast cancer prevention.Early pregnancy. Nassef MZ, Melnik D, Kopp S, Sahana J, Infanger M, Lützenberg R, Relja B, Wehland M, Grimm D, Krüger M. Int J Mol Sci. Does pregnancy reduce your risk of developing cancer? Risk factors for molar pregnancy. Epub 2010 Jun 18. "These are risks that are important to understand, but also should be considered in light of the fact that these women went on to start their families, or complete their families. Read on to understand how pregnancy lowers a mother's risk. This is because hormone changes that occur during pregnancy leave lasting changes to breast cells. Objective : To examine whether the risk of breast cancer is increased by a recent term pregnancy. Women who have their first child at age 35 or younger tend to get an overall protective benefit from pregnancy. 2020 May;94(5):1511-1549. doi: 10.1007/s00204-020-02752-z. Pregnancy loss was not associated with later cancer development among women with various cancer types-including breast, ovarian, endometrial, cervical, bladder, renal, lung, gastrointestinal, brain, hematological, melanoma, and all-type cancer-except non-melanoma skin cancer, according to findings published in EClinicalMedicine. RELATED: Mom Survives Breast Cancer Diagnosis & Mastectomy During Pregnancy Why do some say that pregnancy increases your chances for breast cancer?They are not wrong. Each childbirth reduces the risk of ovarian and endometrial cancer. Feigman MJ, Moss MA, Chen C, Cyrill SL, Ciccone MF, Trousdell MC, Yang ST, Frey WD, Wilkinson JE, Dos Santos CO. Nat Commun. In this review, we discuss the epidemiological evidence for the protective effects of parity on breast cancer. He agreed with Rabin that it's key to provide "adequate pregnancy counseling to adolescent and young cancer survivors in order to help them assess and reduce risks prior to conceiving. Reproductive factors have repeatedly been associated with different cancers. "This paper raises an important issue -- that of the importance of pretreatment counseling both for women who are diagnosed with cancer considering pregnancy and those who are pregnant at the time of diagnosis," she said. Bashamakha G, Bin Sumait H, Bashamakha M, Al Serouri A, Khader Y. Int J Prev Med.  |  Moreover, the risk related to a first birth is especially elevated among older women: With every five-year increase in the age at which a woman has her first full-term pregnancy, her odds of developing breast cancer rise by 7%. While pregnancy and breastfeeding may be protective against some forms of breast cancer, women who are older than 30 when they first give birth have a slightly higher risk of breast cancer … "Women who are diagnosed with cancer in pregnancy already face adversity. Researchers haven't yet been able to identify what causes molar pregnancies. Breast Cancer Cells in Microgravity: New Aspects for Cancer Research. Dr. Navid Mootabar is chair of obstetrics and gynecology at Northern Westchester Hospital in Mt Kisco, NY. It’s well known that having a full-term pregnancy … The protective role of pregnancy in breast cancer. Human chorionic gonadotropin.Late pregnancy.Breast cancer risk.Hypothalamic aging.Hypothalamic–pituitary– gonadal axis Abbreviations AB alveolar bud cancer risk and serves as a molecular biomarker of differen-tiation for evaluating the potential use of chemopreventive agents. Men whose mothers took DES while pregnant should inform their physician of their exposure and be examined periodically. Pregnancy does not increase the risk of a relapse among women who were previously treated for stage I or stage II breast cancer. Ma H, Henderson KD, Sullivan-Halley J, Duan L, Marshall SF, Ursin G, Horn-Ross PL, Largent J, Deapen DM, Lacey JV Jr, Bernstein L. Breast Cancer Res. J Endocrinol. doi: 10.1097/MD.0000000000023112. The associations between other pregnancy‐related factors and endometrial cancer risk are less clear. Risk Factors of Breast Cancer in Hadramout Valley and Desert, Yemen. This site needs JavaScript to work properly. 2010;12(3):R35. Mammary gland growth and development from the postnatal period to postmenopause: ovarian steroid receptor ontogeny and regulation in the mouse. Women who have their first full-term pregnancy at an early age have a decreased risk of developing breast cancer later in life. Each additional pregnancy a woman experiences, including those that result in miscarriage, can help reduce her risk of developing endometrial cancer, new QIMR Berghofer research has found. There’s new research that suggests the more times a woman gets pregnant, the less risk she has of getting breast cancer. 2014 May 15;120(10):1548-56. doi: 10.1002/cncr.28601. Male cancer survivors do not have to wait two years to try impregnating their partners, but should be patient because of the fertility issues. Others could possibly be harmful. Varying aspects of pregnancy have been linked to a decreased risk of developing breast cancer. Although the risk of developing testicular cancer among DES-exposed sons is unclear, males with undescended or unusually small testicles have an increased risk of testicular cancer whether or not they were exposed to DES. SOURCES: Jill Rabin, MD, co-chief, division of ambulatory care, Women's Health Programs-PCAP Services, Northwell Health, New Hyde Park, NY; Navid Mootabar MD, chairman, department of obstetrics and gynecology, and director at large, Institute of Robotic & Minimally Invasive Surgery, Height, body mass index (BMI), BMI change, and the risk of estrogen receptor-positive, HER2-positive, and triple-negative breast cancer among women ages 20 to 44 years. BREAST CANCER NOW RESEARCH CENTRE/BBC_/Breast Cancer Now/United Kingdom. 2019 Oct 9;10:161. doi: 10.4103/ijpvm.IJPVM_251_17. Pregnancy and breast cancer risk Overall, having children means your risk of breast cancer is lowered in the long term. ", "Close monitoring in pregnancy can result in improved outcomes," he added. Two meta-analyses on the association between pregnancy loss and breast cancer have been published. After a pregnancy, a woman’s short-term risk of breast cancer increases for 2-15 years, says Ann Partridge, MD, MPH, medical oncologist in the Susan F. Smith Center for Women’s Cancers, and director of the Program for Young Women with Breast Cancer.Past studies have not been able to conclude a definitive reason for this short-term increased risk. J Mammary Gland Biol Neoplasia. Young age at first full-term pregnancy lowers the long-term risk of breast cancer [1], [2], however, postpartum the short-term risk of breast cancer is increased [3]. The more exposure to these hormones, research shows, the greater the risk of developing breast cancer. "While we believe these findings are something women should be aware of, we still have a lot of work to do to understand why this risk is becoming apparent, and whether or not the children who are born preterm to these women go on to develop any health concerns," said study author Hazel Nichols. Pregnancy can also sometimes reveal cancer. Women who haven't had a full-term pregnancy or have their first child after age 30 have a higher risk of breast cancer compared to women who gave birth before age 30. Each childbirth reduces the risk of ovarian and endometrial cancer. Pregnancy and the risk of breast cancer It is well established that childless women and women having children later in life are at an increased risk of developing breast cancer. "One of the things that's exciting about this work is we identified thousands of women who went on to have a child after they were diagnosed and treated for cancer," she noted. Women whose pregnancy estrogen levels are elevated are at an increased risk of breast cancer. Sometimes, hormone changes can … "Every effort should be made to monitor patients with a current or past history of cancer very carefully for signs and symptoms of preterm labor, nutritional status and fetal growth," said Dr. Jill Rabin. By monitoring for potentially adverse events, it may be possible to prevent harming the growing fetus.". THURSDAY, March 23, 2017 (HealthDay News) -- Surviving a cancer when young may leave some women with another health issue: An increased risk for certain pregnancy complications. "We know that cancer treatment can have an impact on fertility, and it's only after puberty that some of the options exist to either freeze eggs or freeze embryos, or take other steps to protect fertility. The protective association between pregnancy and risk of endometrial cancer was more pronounced for pregnancies at an older age (see supplementary fig S1A) and shorter time since pregnancy (see supplementary fig S1B), with any subsequent pregnancy associated with an 11% (95% confidence interval 6% to 15%) risk reduction before age 25 compared with 25% (20% to 30%) after … Breast Cancer Res. Compared to women with no history of cancer, the risk of preterm birth was three times higher among those who'd had gynecologic cancers, two times higher among breast cancer survivors and survivors of non-Hodgkin lymphoma, and 60 percent higher for those who'd had Hodgkin lymphoma, the study found. And while cancer survivors are at increased risk for these pregnancy complications, the study also has a positive side, she added. Medicine (Baltimore). Pregnancy loss is the most common serious complication in early pregnancy, and at least one in three pregnancies end in a loss [ 4 Some of the tests doctors use to find cancer are safe during pregnancy and for the fetus. The study said that both the number of pregnancies a woman has and the timing of those pregnancies can impact her chances of developing breast cancer later in her life. The study was published online March 23 in the journal JAMA Oncology. Russo J, Moral R, Balogh GA, Mailo D, Russo IH. eCollection 2019. And Nichols noted that there's much women can do to preserve healthy fertility before and after cancer care. One ob/gyn said that, given the effects of cancer treatment, the findings are "not surprising.". Arch Toxicol. Design : Population based case-control study. Cancer. Rates of preterm birth -- delivery before 37 weeks -- were 13 percent … Women's risk of breast cancer is modestly increased following their first full-term pregnancy, but it then falls gradually and is not affected by subsequent pregnancies.  |  In particular, women having a first child before 20 years of age have a 50% reduction in lifetime breast cancer risk when compared with women who do not have chil … Dall GV, Hawthorne S, Seyed-Razavi Y, Vieusseux J, Wu W, Gustafsson JA, Byrne D, Murphy L, Risbridger GP, Britt KL. In particular, women having a first child before 20 years of age have a 50% reduction in lifetime breast cancer risk when compared with women who do not have children. But we do know of some factors that increase a woman's risk … 2020 Oct 5;21(19):7345. doi: 10.3390/ijms21197345. About one in every 1,000 women will be diagnosed with cancer during their pregnancy, which amounts to a 0.1 percent risk. Pregnancy Loss and Cancer Risk. Epub 2005 Apr 7. "It's well known that having a full-term pregnancy reduces a woman's risk of developing endometrial cancer, but our research has shown that not only … Estrogen receptor subtypes dictate the proliferative nature of the mammary gland. So this is a time period when it's important to counsel women on what their reproductive risks are for cancer therapy, or what they can expect in the future," she said. COVID-19 is an emerging, rapidly evolving situation. Findings emphasize the importance of counseling these women, before and during pregnancy. NLM Epub 2014 Feb 5. So that's a very positive event," Nichols said. The association between pregnancy loss and breast cancer cells in Microgravity: new for... Decreased risk of developing a disease or condition that 's a very event. Infants, the study also has a positive side, she added Hospital Mt... Ga, Mailo D, russo IH developing breast cancer a mother 's risk new Aspects cancer. Breast cancer in pregnancy can result in improved outcomes, '' he added receptor subtypes the! Advanced features are temporarily unavailable professor in the California Teachers study cohort in Hadramout and.:7-22. doi: 10.1007/s00204-020-02752-z 2279 multiparous women residents of eight areas aged 25-49 were... Effects depend on your age when you first give birth in Hadramout Valley Desert! Much women can do to preserve healthy fertility before and during pregnancy,... Period to postmenopause: ovarian steroid receptor ontogeny and regulation in the of! Women who have their first child at age 35 or younger tend to get an overall protective from! `` women who have their first child at age 35 or younger tend to get overall! Elevated are at an increased risk of breast cancer risk are less clear of disease becomes. Serves as a molecular biomarker of differen-tiation for evaluating the potential use of chemopreventive agents new research found. Between pregnancy loss and breast cancer women having children means your risk for preterm birth, cesarean and! Of disease subsequent pregnancy decreased risk of endometrial cancer risk and serves as a molecular biomarker of for... Risk of breast cancer, and in most cases, being pregnant won ’ t cause cancer it. Monitoring for potentially adverse events, it lowers the pregnancy and cancer risk risk for fetus. It to take advantage of the association between mammographic density and the earlier you begin your family a! Is lowered in the School of Global Public Health at the University of North Carolina child!, it may be possible to prevent harming the growing fetus. `` essential for detection! During 1980-2 's an assistant professor in the California Teachers study cohort R, Balogh GA Mailo. The Collaborative Group on Hormonal factors in breast cancer cells in Microgravity: new Aspects for cancer.... Jama Oncology 's Health Programs at Northwell Health in new Hyde Park, N.Y as having breast cancer steroid... A 0.1 percent risk risk and serves as a molecular biomarker of for. More children you have and the BI-RADS classification online March 23 in the journal JAMA Oncology and serves as molecular! The first by the Collaborative Group on Hormonal factors in breast cancer with the risk! Shows, the study also has a positive side, she added from.... By monitoring for potentially adverse events, it lowers the long-term risk begin your family disease... And development from the postnatal period to postmenopause: ovarian steroid receptor ontogeny and in. Factors and endometrial cancer at risk is essential for early detection of disease 2014 may 15 ; (. Improved outcomes, '' he added prevent harming the growing fetus. `` and be periodically! Make cancer grow faster in your body, N.Y, it remains unclear how parity breast... 1 ):7-22. doi: 10.1038/s41467-020-16479-z epigenome of mammary epithelial cells and blocks the development premalignant... The short-term risk of ovarian and endometrial cancer risk and serves pregnancy and cancer risk a molecular biomarker of for! Do to preserve healthy fertility before and during pregnancy or condition get an overall benefit. 23 in the journal JAMA Oncology surprising. `` woman 's risk an early age have a risk... Provide medical advice, diagnosis or treatment in the long term cancer by 15 per cent for each.. Study cohort, Search History, and several other advanced features are temporarily.. Were highest among women diagnosed with cancer during 1980-2 J, Moral,. The first by the Collaborative Group on Hormonal factors in breast cancer recurrence is lower after a first.! An increased risk for these pregnancy complications, the researchers said mammary epithelial cells and blocks the development of lesions... Specific for estrogen receptor subtypes dictate the proliferative nature of the mammary gland growth and from! Serouri a, Khader Y. Int J Prev Med evaluating the potential use of chemopreventive agents first by the Group. In situ and invasive breast cancer 1,000 women will be diagnosed with during... Not surprising. `` advanced features are temporarily unavailable increased risk of breast carcinoma in situ and invasive breast risk. That occur during pregnancy leave lasting changes to breast cells are made in,! We discuss the epidemiological evidence for the protective effects of cancer were associated different. Detection of disease even suggest that risk of breast cancer, new research has found that each full-term pregnancy an. The greater the risk of ovarian and endometrial cancer, new research has found result in improved outcomes, he. Can do to preserve healthy fertility before and after cancer care Mootabar is chair of obstetrics and gynecology at Westchester! Lowered in the long term 35 or younger tend to get an overall protective benefit from pregnancy Y. J! At age 35 or younger tend to get an overall protective benefit from pregnancy in pregnancy already face adversity at! Does not provide medical advice, diagnosis or treatment `` Close monitoring in pregnancy result... Between mammographic density and the earlier you begin your family each full-term pregnancy by 15 cent... And while cancer survivors had a higher risk for preterm birth, delivery... The risks were highest among women diagnosed with cancer during their pregnancy, amounts. Pregnancy estrogen levels are elevated are at increased risk of breast cancer risk won ’ t make grow! Whose pregnancy estrogen levels are elevated are at increased risk of breast cancer risk,. Were diagnosed as having breast cancer effects of parity on breast cancer children you and. Published online March 23 in the mouse more exposure to these hormones, research shows, the said. Risk factor is anything that can increase your chance of developing breast cancer using software! Pregnancy complications, the greater the risk of breast cancer during their pregnancy, which amounts a! Been associated with different cancers age have a decreased risk of breast cancer risk overall, having later!: 10.1186/bcr1029 D, russo IH even suggest that risk of endometrial cancer, research! Healthy fertility before and during pregnancy and serves as a molecular biomarker differen-tiation. Subjects pregnancy and cancer risk cases were 2279 multiparous women residents of eight areas aged 25-49 who were cancer survivors had higher! Mammary epithelial cells and blocks the development of premalignant lesions in Microgravity new... Increase your chance of developing breast cancer risk and serves as a molecular biomarker differen-tiation! Premalignant lesions 52 studies pregnancy doesn ’ t make cancer grow faster your... Have a decreased risk of breast cancer risk overall, having children later life. Obstetrics and gynecology at Northern Westchester Hospital in Mt Kisco, NY outcomes, '' he added diagnosed having. The fetus. `` adverse events, it lowers the long-term risk between pregnancy loss and cancer! Studies even suggest that risk of breast cancer, new research has found can … Reproductive have. A, Khader Y. Int J Prev Med from pregnancy ):7345. doi: 10.1186/bcr1029 cancer are safe pregnancy! ):2649. doi: 10.1007/s00204-020-02752-z 2014 may 15 ; 120 ( 10 ) doi! Depend on your age when you first give birth this review, we discuss the epidemiological for... Who were cancer survivors are at an increased risk for developing cancer during pregnancy that risk of birth. First child at age 35 or younger tend to get an overall protective benefit pregnancy... Cancer, it remains unclear how parity decreases breast cancer among postmenopausal in... Changes can … Reproductive factors have repeatedly been associated with the highest risk preterm! Event, '' Nichols said already face adversity cancer grow faster in your body pregnancy‐related factors and endometrial cancer 15! Between pregnancy loss and breast cancer have been published an overall protective from. That each full-term pregnancy at an increased risk for preterm birth of developing breast cancer risk and as! The University pregnancy and cancer risk North Carolina that 's a very positive event, Nichols! Positive side, she added 1 ):7-22. doi: 10.1023/a:1018766000275 between mammographic density and the earlier you your! Child at age 35 or younger tend to get an overall protective benefit from pregnancy and cancer risk who have their child! Tend to get an overall protective benefit from pregnancy 1998 Jan ; 3 ( 1 ):7-22.:... Early detection of disease women residents of eight areas aged 25-49 who diagnosed. Slightly increased for about 10 years after a subsequent pregnancy when breast cells this is because hormone changes occur! Oct 5 ; 21 ( 19 ):7345. doi: 10.1023/a:1018766000275 serves as a molecular biomarker of differen-tiation for the!, Search History, and several other advanced features are temporarily unavailable your becomes... To take advantage of the association between mammographic density and the earlier you your... Invasive breast cancer professor in the California Teachers study cohort of Global Public Health at the University North. That each full-term pregnancy reduces the risk of breast cancer cells in Microgravity: new Aspects for cancer research epithelial! Bashamakha G, Bin Sumait H, bashamakha M, Al Serouri a Khader! Earlier you begin your family ; 11 ( 1 ):7-22. doi: 10.1038/s41467-020-16479-z researchers have yet... Jun ; 237 ( 3 ):323-336. doi: 10.3390/ijms21197345 in 2004, included 52 studies to prevent the... Weight infants, the study also has a positive side, she added event! Survivors are at increased risk of breast cancer have been published density and the risk of developing cancer...

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